Gestational trophoblastic diseases (GTD): Causes, signs and symptoms, treatment and prevention
What is Gestational trophoblastic diseases (GTD) ? These are a condition occurring when there is abnormal development, usually the over-proliferation of the chorionic villi. GTD can either lead to partial or complete hydatidiform mole. There is viable fetus despite the rising of the hCG in the woman’s urine and blood serum. In other words, GTD is a spectrum of neoplastic disorders originating from placental development. Gestational tissue is present, but the pregnancy is not viable. How common is Gestational trophoblastic disease The incident rate is 1:1, 000 pregnancies in United Kingdom but up to 15 times higher in Asian countries. Types of Gestational trophoblastic diseases There are two most common types of GTD namely: Risk factors for GTD Signs and symptoms of GTDs GTD is a benign condition which usually manifests in second trimester of pregnancy with the following signs and symptoms: Molar pregnancy/hydatidiform mole Hydatidiform mole is a benign neoplasm of the chorion in which the chronic villi degenerate and become transparent vesicles containing clear, viscid fluid. Pathophysiology: How molar pregnancy develops Hydatidiform mole is a benign neoplasm of the chorion in which the chronic villi degenerate and become transparent vesicles containing clear, viscid fluid. Hydatidiform mole is classified as complete or partial, distinguished by differences in clinical presentation, pathology, genetics and epidemiology. The complete mole contains no fetal tissue and develops from an empty egg which is fertilized by a normal sperm. The paternal chromosomes replicate resulting in 46 all paternal chromosomes. The embryo is not viable and dies. No circulation is established and no embryonic tissue is found. The complete mole is associated with the development of choriocarcinoma. The partial mole has a triploid Karyotype (69 chromosomes), because two sperm have provided a double contribution by fertilizing the ovum. Types of molar pregnancy/ Hydatidiform mole Hydatidiform mole is classified as complete or partial, distinguished by differences in clinical presentation, pathology, genetics and epidemiology. What are the differences between complete and partial mole? Complete mole Partial mole Generalized trophoblastic hyperplasia Focal trophoblastic hyperplasia Generalized swelling of villous tissue Focal swelling of villous tissue No embryonic or fetal parts Embryonic/fetal part is present Chromosomal constituent is usually 46, XY or 46, XX Chromosomal constituent is usually 69, XXY or 60, XXX Contains only paternal genome Contains both paternal and maternal genome Causes of molar pregnancy The exact cause of molar pregnancy is unknown but researchers are looking into a genetic basis. Studies have revealed some remarkable features about molar pregnancies including: How to diagnose Gestational trophoblastic diseases Rapid continuous rise in hCG may be a diagnostic clue for GTD which needs to be confirmed by antenatal ultrasound screening. Diagnosis is made through ultrasound revealing appearance of vesicular molar pattern. Nursing assessment for molar pregnancy The nurse (midwife) plays a crucial role in identifying this condition and notifying obstetrician. Bases on sound knowledge of clinical manifestation and expertise antenatal assessments, clinical manifestation of GTD is similar to those of spontaneous abortion at about 12 weeks of pregnancy. The following symptoms will alert the midwife about GTD. Management of Gestational trophoblastic diseases Treatment of molar pregnancy is by both medical and nursing approaches. Medical treatment for molar pregnancy: Treatment consists of immediate evacuation of uterine content as soon as the diagnosis is made and long-term follows up of the client to detect any remaining trophoblastic tissue that might become malignant. This is then followed by histologic examination of the tissue to enhance accurate diagnosis of molar pregnancy. It is carried out with manual or electrical vacuum aspiration. The tissue obtained is sent for choriocarcinoma. Women with Rhesus negative factor are highly recommended to receive Anti-D immunoglobulin following a molar pregnancy evacuation. This is encouraged until everything stabilizes (hCG being in pregravid state and the woman being fit). Serial levels of hCG help detect residual trophoblastic tissue for 1 year because if any tissue remains, hCG levels will not drop. In 80% of women with a benign hydatidiform mole, serum hCG titers steadily drop to normal within 8 – 12 weeks after evacuation 20% of women with a malignant hydatidiform mole, serum hCG levels begin to rise. Due to increased risk of cancer, the patient is advised to receive extensive follow-up therapy for the next 12 months. While in subsequent pregnancies, hCG levels are meticulously monitored for about 6-8weeks of gestation to confirm that molar pregnancy does not occur again. The following-up protocol for GTD include: Nursing management for molar pregnancy The aims of nursing management are: Preparing the client Once diagnosis is made, immediate evacuation is needed, prepare the client physically and psychologically for the procedure. Providing emotional support Educating the client Complications of GTD If the molar pregnancy is not evacuated on time or does not spontaneously miscarry, it can result in these disorders: Prevention of Molar pregnancy There is no specific way of preventing hydatidiform mole. However, women at higher risk of molar pregnancy are encouraged to embrace contraception. Or if they become pregnancy, the women should endeavour to book for antenatal care on time where ultrasound screening and other supportive investigations would be recommended and performed.